Betaine, also called trimethylglycine, is a naturally occurring compound found in foods including beets, spinach, wheat, and quinoa. In the body, it functions as an osmolyte, a molecule that helps cells maintain water balance when conditions around them change.

That osmoprotective property makes betaine particularly interesting for oral care. Evena provides 123.53 mg per serving based on certificate-of-analysis testing, slightly above its 100 mg label claim.

Designed to:

Support oral moisture and comfort overnight.

What Research Suggests

A randomized, double-blind clinical trial in people with dry mouth found that a detergent-free toothpaste containing 4% betaine significantly improved measures including lip dryness and difficulty eating.

The betaine toothpaste relieved dry-mouth symptoms in 44% of participants with xerostomia, compared with 7% using the reference toothpaste.

https://pubmed.ncbi.nlm.nih.gov/12761586/

An earlier double-blind crossover study found that toothpaste containing 4% betaine significantly relieved several subjective dry-mouth symptoms.

The study did not find significant changes in plaque or oral levels of mutans streptococci, lactobacilli, or Candida, supporting betaine’s role primarily as a moisture- and comfort-focused ingredient rather than an antimicrobial one.

https://doi.org/10.1080/00016359850136003

A randomized controlled trial in 51 people compared a betaine-based mouthwash, a malic-acid spray, and placebo. All groups improved in dry-mouth sensation and unstimulated salivary flow, so betaine did not separate from placebo on those measures. However, oral-health-related quality of life improved significantly with the betaine-containing mouthwash.

https://pubmed.ncbi.nlm.nih.gov/33574994/

A clinical study of topical dry-mouth products containing betaine, xylitol, and olive oil found increased unstimulated salivary flow, fewer dry-mouth complaints, and improved dry-mouth-related quality of life.

Because several ingredients were used together, betaine’s individual contribution cannot be separated from the overall formulation.

https://pubmed.ncbi.nlm.nih.gov/17824884/

What This Means

Human clinical research supports the use of betaine-containing oral-care products for oral moisture and dry-mouth comfort.

Betaine’s role is primarily environmental rather than antibacterial. As an osmoprotectant, it helps cells maintain hydration and water balance. This is particularly relevant overnight, when natural salivary flow decreases.

The existing oral research has primarily used toothpastes, mouthwashes, and other topical products rather than dissolving tablets. Tablet-specific clinical data are not currently available.

Evena’s Use of Betaine

Evena includes betaine to support oral moisture and comfort through the night, complementing the formula’s microbiome-focused ingredients.*

Evena provides 123.53 mg of betaine per serving based on certificate-of-analysis testing, slightly above its 100 mg label claim.

Its role is simple but important: help support the oral environment during the overnight hours when natural saliva flow is reduced.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This information is provided for educational purposes only and is not medical advice. Individual results may vary.